{"id":2388,"date":"2018-08-18T19:18:08","date_gmt":"2018-08-18T09:18:08","guid":{"rendered":"https:\/\/doseme-rx.com\/?p=2388"},"modified":"2021-04-13T11:50:07","modified_gmt":"2021-04-13T01:50:07","slug":"prediction-of-vancomycin-levels","status":"publish","type":"post","link":"https:\/\/doseme-rx.com\/de\/vancomycin\/whitepapers\/prediction-of-vancomycin-levels","title":{"rendered":"Accurate Prediction of Vancomycin Levels to Optimize Care"},"content":{"rendered":"\n

DoseMeRx Leverages Pharmacometrics for Dose Optimization of Vancomycin<\/h2>\n\n\n\n
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DoseMeRx is unique precision dosing software that incorporates clinically validated pharmacokinetic drug models, patient characteristics, drug concentrations and genotype (if applicable and available) to guide dose optimization.<\/p>\n\n\n\n

Designed exclusively to support physicians in making a rigorous, best-practice decision based on maximizing the use of readily available patient data via pathology and other sources.<\/p>\n<\/div>\n\n\n\n

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Individualize doses to any therapeutic target<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Custom physiciandriven dosing<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Hospital Guidelines<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Drug label dosing<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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Indvidualized dose recommendations in target trough range<\/p>\n<\/div>\n\n\n\n

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Reduction in supra-therapeutic troughs<\/p>\n<\/div>\n\n\n\n

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Make use of every vancomycin concentration, including those outside of the recommended time predose<\/p>\n<\/div>\n<\/div>\n\n\n\n

How Accurate is DoseMeRx at Predicting a Concentration?<\/h2>\n\n\n\n
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DoseMeRx can accurately predict the concentration of vancomycin levels with low error relative to the target trough range (10-20mcg\/mL):<\/p>\n\n\n\n

Mean Error: 1.2mcg\/mL<\/h5>\n\n\n\n
Mean Absolute Error: 2.9mcg\/mL<\/h5>\n<\/div>\n\n\n\n
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DoseMeRx maximizes
\nthe use of every
\nvancomycin
\nconcentration, even
\nthose outside of the
\nrecommended time
\npre-dose.<\/p><\/blockquote>\n<\/div>\n<\/div>\n\n\n\n

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DoseMeRx can place 84% of doses into the target range, and is significantly less likely to result in overexposure, reducing patients at risk of acute kidney injury from 27% to 10% of doses.<\/p>\n\n\n\n

Without DoseMeRx, only 1 in 2 doses achieved troughs considered therapeutic by the AME guidelines1. Why is this proportion so low?<\/p>\n<\/div>\n<\/div>\n\n\n\n

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  1.  Only 14% of vancomycin levels were taken within AME guidelines of within 30 minutes prior to a dose. The mean time that a level was taken prior to the next dose was 320 minutes (5.3 hours). Without model-informed dosing, such as DoseMeRx, these levels are largely useless.<\/li>
  2.  Vancomycin has high inter-individual variability. Studies show that the vancomycin dose-effect relationship is sufficiently variable that a population of patients receiving 1000mg bd can have trough levels ranging from 5.3\u201372.6mcg\/mL2<\/sup><\/li><\/ol>\n<\/div>\n<\/div>\n\n\n\n
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    Reduce the risk of vancomycin nephrotoxicity with DoseMeRx<\/h2>\n\n\n\n
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    Nephrotoxicity is a major concern for vancomycin
    \ndosing, and a significant adverse event 3<\/sup>.
    \nThe literature supports precision dosing using
    \ndecision support software like DoseMeRx as an
    \neffective approach to optimizing vancomycin dosing 4<\/sup>.<\/p>\n\n\n\n

    DoseMeRx consistently and more accurately can calculate a dose to place a patient in the therapeutic range. The accuracy of DoseMeRx allows physicians to significantly decrease the proportion of vancomycin doses with supra-therapeutic troughs from 3\/10 to 1\/10.<\/p>\n<\/div>\n\n\n\n

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    The proportion
    \nof patients at risk for
    \nvancomycin-induced
    \nnephrotoxicity risk
    \ncan be significantly
    \nreduced with
    \nprecision dosing.<\/p><\/blockquote>\n<\/div>\n<\/div>\n\n\n\n

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    Vancomycin Dosing and Monitoring<\/h2>\n\n\n\n
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    Vancomycin has a narrow therapeutic range, with clinical practice targeting a therapeutic trough of 15-20mcg\/mL. Toxicity of vancomycin is exposure-dependent, with high trough concentrations shown to significantly increase risk of nephrotoxicity5,6<\/sup>. Accurately reaching therapeutic targets is critical to effective treatment and minimization of antimicrobial resistance7<\/sup>.<\/p>\n<\/div>\n\n\n\n

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    DoseMeRx allows<\/p>

    calculation of<\/p>

    both trough<\/p>

    or AUC24.<\/p><\/blockquote>\n<\/div>\n<\/div>\n\n\n\n

    The Evaluation<\/b><\/p>\n\n\n\n

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    Data<\/strong><\/p>\n\n\n\n