{"id":9937,"date":"2023-03-16T00:36:31","date_gmt":"2023-03-15T14:36:31","guid":{"rendered":"https:\/\/doseme-rx.com\/?p=9937"},"modified":"2025-01-22T05:46:12","modified_gmt":"2025-01-21T19:46:12","slug":"bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies","status":"publish","type":"post","link":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies","title":{"rendered":"Bayesian Dosing of Tobramycin Outperforms Other Personalized Dosing Strategies at Pediatric Hospital"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\"><\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">DoseMeRx Reduces Labs, Saves Time &amp; Money at The Children\u2019s Hospital at Westmead<\/h2>\n\n\n\n<p>A study published in September 2022 in the Journal of Antimicrobial Chemotherapy demonstrated that Bayesian dosing (BD) of tobramycin in children with cystic fibrosis (CF) had fewer blood collections, higher dosing accuracy, and more reliable target concentration attainment compared to log-linear regression (LLR).<sup>1<\/sup>&nbsp;<\/p>\n\n\n\n<p>This study was performed between 2015 and 2021 at <a href=\"https:\/\/www.schn.health.nsw.gov.au\/hospitals\/chw\" target=\"_blank\" rel=\"noreferrer noopener\">The Children\u2019s Hospital at Westmead<\/a> in Australia after their transition to AUC-guided Bayesian dosing using DoseMeRx.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Key Findings<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The use of <strong>DoseMeRx improved dosing accuracy, reducing the risk of AKI <\/strong>and antibiotic resistance.<\/li>\n\n\n\n<li>Compared to other personalized dosing strategies, <strong>DoseMeRx significantly reduces the number of AUC<sub>0-24<\/sub> calculations<\/strong> needed.<\/li>\n\n\n\n<li><strong>DoseMeRx cut the number of blood collections in half <\/strong>compared to other personalized dosing methods, saving time and money as well as reducing patient stress.<\/li>\n<\/ul>\n\n\n\n<p><br>Before we look more closely at the results of this study, let\u2019s review cystic fibrosis and tobramycin dosing.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/iStock-894463832_ped-pic-1-1024x683.jpg\" alt=\"\" class=\"wp-image-9952\" srcset=\"https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/iStock-894463832_ped-pic-1-1024x683.jpg 1024w, https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/iStock-894463832_ped-pic-1-300x200.jpg 300w, https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/iStock-894463832_ped-pic-1-768x512.jpg 768w, https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/iStock-894463832_ped-pic-1-1536x1025.jpg 1536w, https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/iStock-894463832_ped-pic-1-2048x1367.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">What Is Cystic Fibrosis?<\/h2>\n\n\n\n<p>Almost 40,000 children and adults in the United States are living with cystic fibrosis.<sup>2<\/sup> CF impacts multiple organ systems, including the lungs, pancreas, and gastrointestinal system.<sup>3<\/sup> It is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.<sup>4<\/sup> Missing or defective CFTR proteins result in thicker and stickier mucus that no longer acts as a lubricant and affects the function of multiple organ systems.<sup>4<\/sup>&nbsp;<\/p>\n\n\n\n<p>Pulmonary deterioration is the primary cause of morbidity and mortality in CF. The clinical course of CF typically involves periods of worsening lung function, known as an acute pulmonary exacerbation.<sup>5,6<\/sup><\/p>\n\n\n\n<p>Acute pulmonary exacerbations are caused by microorganisms that opportunistically colonize the airway in CF patients.<sup>7<\/sup> The thick layer of mucus and decreased clearance in CF patients can create an anaerobic environment in the lungs, ideal for facultative anaerobes like <em>Pseudomonas aeruginosa<\/em>.<sup>8<\/sup> Colonization with <em>P. aeruginosa<\/em> is a significant predictor of morbidity and mortality in CF patients.<sup>9<\/sup>&nbsp;<\/p>\n\n\n\n<p>Other bacteria that are commonly isolated from the airways of patients with CF include:<sup>8<\/sup><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>Staphylococcus aureus&nbsp;<\/em><\/li>\n\n\n\n<li><em>Burkholderia cepacia&nbsp;<\/em><\/li>\n\n\n\n<li><em>Haemophilus influenzae<\/em><\/li>\n\n\n\n<li>Non-tuberculosis <em>Mycobacteria species<\/em><br><\/li>\n<\/ul>\n\n\n\n<p>Acute pulmonary exacerbations are commonly treated with antibiotics such as tobramycin.<sup>10<\/sup> However, the impact on pharmacokinetic parameters in patients with CF can complicate dosing narrow therapeutic index drugs like tobramycin.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">How Does CF Affect the Pharmacokinetics of Tobramycin?<\/h3>\n\n\n\n<p>Patients with CF often need a higher dose of tobramycin compared to the general population because of altered pharmacokinetics.<sup>11<\/sup> Several factors contribute to the altered pharmacokinetics of tobramycin in patients with CF. <sup>12<\/sup><\/p>\n\n\n\n<p>The thick mucus produced by patients with CF can make it difficult for systemic tobramycin to penetrate the lungs.<sup>13<\/sup><\/p>\n\n\n\n<p>Patients with CF typically have an increased volume of distribution for tobramycin. This is due to decreased adipose tissue compared to the general population, caused by undernourishment.<sup>14<\/sup>&nbsp;<\/p>\n\n\n\n<p>Renal function in CF is frequently variable and can be difficult to predict. Some studies show increased renal clearance of aminoglycosides in patients with CF.<sup>14<\/sup> However, patients with advanced disease can have impaired kidney function. Because of reduced muscle mass in CF patients, serum creatinine is not always a reliable marker of kidney function\u2014resulting in an overestimation of kidney function.<sup>15<\/sup>&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Personalized Tobramycin Dosing<\/h2>\n\n\n\n<p>Tobramycin is an aminoglycoside antibiotic commonly used for empiric treatment of acute pulmonary exacerbations in CF, due to its <em>Pseudomonas<\/em> coverage.<sup>10<\/sup>&nbsp;<\/p>\n\n\n\n<p>Dosing strategies for tobramycin have aimed to reduce the toxicity of tobramycin while preserving its efficacy. Over the years, tobramycin dosing has evolved from being dosed every 8 to 12 hours to the now widely accepted once-daily dosing.&nbsp;<\/p>\n\n\n\n<p>It has a concentration-dependent effect, meaning it is more effective at higher concentrations. However, the dose of tobramycin is limited by its potential adverse effects, such as:<sup>10<\/sup><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Nephrotoxicity<\/li>\n\n\n\n<li>Ototoxicity<\/li>\n\n\n\n<li>Vestibular toxicity&nbsp;<\/li>\n<\/ul>\n\n\n\n<p><br>Repeated and long-term exposure to aminoglycosides will increase the risk of nephrotoxicity and ototoxicity. This risk is especially important in patients with CF since they have a high risk of multiple antibiotic exposures over their lifetime.<sup>16<\/sup>&nbsp;<\/p>\n\n\n\n<p>After an empirical dose is prescribed, personalized tobramycin dosing can be guided by therapeutic drug monitoring (TDM). Two common tobramycin dosing strategies are log-linear regression and Bayesian dosing.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Log-Linear Regression Dosing<\/h3>\n\n\n\n<p>The LLR method involves collecting two blood tobramycin concentrations at specific times. These two measurements are used to calculate the AUC from 0 to 24 hours (AUC<sub>0-24<\/sub>).<sup>17<\/sup>&nbsp;<\/p>\n\n\n\n<p>In addition to requiring two separate blood collections, which can be stressful for patients, this method is also time-consuming for pharmacists to calculate the dose.<\/p>\n\n\n\n<p>Calculating a tobramycin dose using LLR involves manually entering the two tobramycin blood concentrations into a Microsoft Excel spreadsheet embedded with the appropriate pharmacokinetic equations. Because the input is done manually, it may also be prone to transcription errors.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Bayesian Dosing<\/h3>\n\n\n\n<p>Bayesian dosing software, such as DoseMeRx, uses population pharmacokinetic data to calculate the tobramycin dose.<\/p>\n\n\n\n<p>Only one blood tobramycin concentration taken at any time after the infusion to estimate &nbsp;&nbsp;&nbsp;AUC<sub>0-24<\/sub> is needed for Bayesian dosing.<\/p>\n\n\n\n<p>Bayesian dosing platforms like DoseMeRx can improve accuracy and save time by <a href=\"https:\/\/doseme-rx.com\/why-dosemerx\/product\/integrations\">integrating<\/a> into the electronic health record (EHR), versus manual input for LLR dosing.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Bayesian Dosing of Tobramycin Offers Clinical and Practical Advantages Over Other Personalized Dosing Strategies<\/h2>\n\n\n\n<p>Now that we have reviewed CF and tobramycin dosing, let\u2019s dig into this study\u2019s results.&nbsp;<\/p>\n\n\n\n<p>The goal of this study was to compare the clinical and performance outcomes of LLR and Bayesian dosing strategies in children with CF being treated for acute pulmonary exacerbations.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Which Outcomes Were Measured?<\/h3>\n\n\n\n<p>The primary clinical outcomes were:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Length of stay (LOS) in the hospital<\/li>\n\n\n\n<li>Unexpected hospital readmission within one month after initial discharge&nbsp;<\/li>\n\n\n\n<li>Pulmonary function measured by \u0394FEV<sub>1<\/sub> \u2014 the change in forced expiratory volume in the first second from hospital admission to discharge<\/li>\n\n\n\n<li>Rate of acute kidney injury (AKI) \u2014 defined as a second blood test showing an increase in baseline serum creatinine (SCr) of 1.5 times or more during the hospital stay&nbsp;<\/li>\n<\/ul>\n\n\n\n<p><br>The performance outcomes were:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Number and timing of tobramycin TDM blood samples collected<\/li>\n\n\n\n<li>Initial dose selection<\/li>\n\n\n\n<li>Final maintenance dose&nbsp;<\/li>\n\n\n\n<li>Frequency and precision of target concentration attainment<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><br>Baseline Characteristics<\/h3>\n\n\n\n<p>A total of 376 hospital admissions for CF pulmonary exacerbation were included in this study. LLR dosing was used in 248 (66%) of admissions and BD was used in 128 (34%) of admissions. The patient demographics (gender ratios, age, weight, and BMI) were similar between the LLR and Bayesian dosing (BD) cohorts.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Benefits of Bayesian Dosing Did This Study Find?<\/h2>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile has-lightgold-background-color has-background\" style=\"font-size:10px;grid-template-columns:19% auto\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" width=\"449\" height=\"450\" src=\"https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/Testimonial.png\" alt=\"\" class=\"wp-image-9960 size-full\" srcset=\"https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/Testimonial.png 449w, https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/Testimonial-300x300.png 300w, https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/Testimonial-150x150.png 150w\" sizes=\"(max-width: 449px) 100vw, 449px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"has-darkpurple-color has-text-color has-medium-font-size\"><br><strong><em>\u201cPrograms like DoseMeRx have significantly impacted our clinical workflow when we are so time-poor. I don\u2019t think we can ever return to what we were doing before!\u201d<\/em><\/strong><\/p>\n\n\n\n<p class=\"has-darkpurple-color has-text-color has-small-font-size\"><br>Tony Lai, Senior Pharmacist, Antimicrobial Stewardship<br>The Children&rsquo;s Hospital at Westmead, Australia<\/p>\n<\/div><\/div>\n\n\n\n<p><\/p>\n\n\n\n<p>The statistically significant performance outcomes of the study were:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Patients in the LLR group had about twice as many blood samples collected<\/strong> during their hospital admission (3.8 versus 1.9 for LLR and BD, respectively; P &lt; 0.001)<\/li>\n\n\n\n<li><strong>Patients in the LLR group had a higher percentage of dedicated blood samples<\/strong> taken (74%; 690\/933) compared to the BD group (35%; 86\/249) (P &lt; 0.001)<\/li>\n\n\n\n<li><strong>Fewer patients in the BD group required three or more AUC<\/strong><strong><sub>0-24<\/sub><\/strong><strong> calculations<\/strong> (11%; 14\/128) versus the LLR group (18%; 45\/248) (P = 0.01)<\/li>\n\n\n\n<li><strong>Target AUC<sub>0-24<\/sub> of \u2265100 mg\/L\u00b7h was attained more frequently in the BD group<\/strong> (72%; 92\/128) versus the LLR group (50%; 61\/248) (P = 0.004)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><br>Bayesian Dosing\u2019s Clinical Advantage<\/h3>\n\n\n\n<p>This study demonstrates Bayesian dosing\u2019s clinical advantage over LLR dosing. Even in this notoriously hard-to-dose pediatric CF population, Bayesian dosing had better target AUC<sub>0-24<\/sub> attainment.<\/p>\n\n\n\n<p>Accurate dosing with BD can decrease the risk of AKI and antibiotic resistance, which is especially important for children with CF who will likely have multiple antibiotic exposures in their life.<sup>16<\/sup><\/p>\n\n\n\n<p>BD was also non-inferior to LLR regarding other clinical outcomes such as hospital LOS and \u0394FEV<sub>1<\/sub> in this study.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Bayesian Dosing\u2019s Practical Advantage<\/h3>\n\n\n\n<p><br>Not only is Bayesian dosing more accurate, but it\u2019s also more practical <a href=\"https:\/\/doseme-rx.com\/vancomycin\/article\/bayesian-dosing-free-vs-paid\">than other precision dosing methods<\/a>.<\/p>\n\n\n\n<p>Bayesian dosing only requires one blood sample that can be taken at any time after the infusion is complete. Fewer blood tobramycin concentrations mean fewer venipunctures. This opens opportunities to combine blood samples with other labs to reduce psychological distress for pediatric patients and potentially save money for the institutions.<\/p>\n\n\n\n<p>Bayesian dosing software also saves time and improves accuracy because it does not rely on manual calculations, which are time-consuming and prone to transcription errors. &nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">DoseMeRx Can Help Your Institution Transition to Bayesian Dosing<\/h2>\n\n\n\n<p>Bayesian dosing has been available for more than 20 years and the availability of easy-to-use and efficient software has made it easier than ever to adopt into practice.<sup>18<\/sup> This study shows that there is sufficient support for Bayesian dosing software like DoseMeRx to be advocated as the preferred method of precision drug dosing for tobramycin.<\/p>\n\n\n\n<p>Although there isn\u2019t currently an international consensus on tobramycin TDM, many institutions and guidelines are recognizing the benefit of Bayesian dosing. The Government of South Australia\u2019s tobramycin dosing guidelines recommend manual calculation of AUC only when a software program is not available.<sup>19<\/sup><\/p>\n\n\n\n<p>DoseMeRx uses Bayesian dosing to give personalized tobramycin dosing recommendations for adult, pediatric, and neonatal patients. The dosing <a href=\"https:\/\/doseme-rx.com\/why-dosemerx\/drug-packages\">models<\/a> used by DoseMeRx are validated by a team of bioinformaticians, scientists, and clinical pharmacists.&nbsp;<\/p>\n\n\n\n<p>DoseMeRx\u2019s <a href=\"https:\/\/doseme-rx.com\/why-dosemerx\/product\/integrations\">integrated<\/a> platform can improve your workflow by automatically integrating the patient&rsquo;s data into the dosing software. DoseMeRx\u2019s embedded <a href=\"https:\/\/doseme-rx.com\/why-dosemerx\/product\/analytics\" target=\"_blank\" rel=\"noreferrer noopener\">analytics <\/a>platform can give your team instant access to clinical and statistical dashboards to help visualize institutional trends.&nbsp;<\/p>\n\n\n\n<p><a href=\"https:\/\/doseme-rx.com\/talk-to-a-human\">Get in touch<\/a> to explore how DoseMeRx can help your institution improve patient outcomes while saving time and money.<\/p>\n\n\n<div class=\"trial-form-module form_row\" id=\"bookademo\">\r\n    \r\n<div class=\"copy\">\r\n\t<h2 class=\"has-gold-color has-text-color\">Demandez une d\u00e9mo<\/h2>\r\n\t<p>D\u00e9couvrez \u00e0 quel point DoseMeRx est facile \u00e0 utiliser et \u00e0 int\u00e9grer dans votre journ\u00e9e de travail.<\/p>\n<p>Demandez une d\u00e9mo ci-dessous. Vous pouvez \u00e9galement nous appeler au +1 (832) 358-3308 ou nous envoyer un e-mail \u00e0 <a href=\"mailto:hello@dosemehealth.com\">hello@dosemehealth.com<\/a><\/p>\n<\/div>\t\t\r\n\r\n<script>\r\n\t$(function () {\r\n\t\t\r\n\t\t\r\n\t$.getJSON(\"https:\/\/api.ipstack.com\/check?access_key=2096fae20ea80a0c432c80c876bb462d&output=json\").done(function(e) {\r\n\t\t$(\"#input_11_7\").val(e.ip);\t\t\t\t\r\n\t\t$(\"#input_11_8\").val(e.city + \", \" + e.region_name + \", \" + e.country_name);\r\n\t\t$(\"#input_11_10\").val(e.country_name);\r\n\t\t$(\"#input_11_15\").val(e.continent_name);\r\n\t})\t\t\t\r\n\r\n\t});\r\n\r\n\r\n\t<\/script>\r\n\r\n<script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\nvar gform;gform||(document.addEventListener(\"gform_main_scripts_loaded\",function(){gform.scriptsLoaded=!0}),document.addEventListener(\"gform\/theme\/scripts_loaded\",function(){gform.themeScriptsLoaded=!0}),window.addEventListener(\"DOMContentLoaded\",function(){gform.domLoaded=!0}),gform={domLoaded:!1,scriptsLoaded:!1,themeScriptsLoaded:!1,isFormEditor:()=>\"function\"==typeof InitializeEditor,callIfLoaded:function(o){return!(!gform.domLoaded||!gform.scriptsLoaded||!gform.themeScriptsLoaded&&!gform.isFormEditor()||(gform.isFormEditor()&&console.warn(\"The use of gform.initializeOnLoaded() is deprecated in the form editor context and will be removed in Gravity Forms 3.1.\"),o(),0))},initializeOnLoaded:function(o){gform.callIfLoaded(o)||(document.addEventListener(\"gform_main_scripts_loaded\",()=>{gform.scriptsLoaded=!0,gform.callIfLoaded(o)}),document.addEventListener(\"gform\/theme\/scripts_loaded\",()=>{gform.themeScriptsLoaded=!0,gform.callIfLoaded(o)}),window.addEventListener(\"DOMContentLoaded\",()=>{gform.domLoaded=!0,gform.callIfLoaded(o)}))},hooks:{action:{},filter:{}},addAction:function(o,r,e,t){gform.addHook(\"action\",o,r,e,t)},addFilter:function(o,r,e,t){gform.addHook(\"filter\",o,r,e,t)},doAction:function(o){gform.doHook(\"action\",o,arguments)},applyFilters:function(o){return gform.doHook(\"filter\",o,arguments)},removeAction:function(o,r){gform.removeHook(\"action\",o,r)},removeFilter:function(o,r,e){gform.removeHook(\"filter\",o,r,e)},addHook:function(o,r,e,t,n){null==gform.hooks[o][r]&&(gform.hooks[o][r]=[]);var d=gform.hooks[o][r];null==n&&(n=r+\"_\"+d.length),gform.hooks[o][r].push({tag:n,callable:e,priority:t=null==t?10:t})},doHook:function(r,o,e){var t;if(e=Array.prototype.slice.call(e,1),null!=gform.hooks[r][o]&&((o=gform.hooks[r][o]).sort(function(o,r){return o.priority-r.priority}),o.forEach(function(o){\"function\"!=typeof(t=o.callable)&&(t=window[t]),\"action\"==r?t.apply(null,e):e[0]=t.apply(null,e)})),\"filter\"==r)return e[0]},removeHook:function(o,r,t,n){var e;null!=gform.hooks[o][r]&&(e=(e=gform.hooks[o][r]).filter(function(o,r,e){return!!(null!=n&&n!=o.tag||null!=t&&t!=o.priority)}),gform.hooks[o][r]=e)}});\n\/* ]]> *\/\n<\/script>\n\n                <div class='gf_browser_gecko gform_wrapper gravity-theme gform-theme--no-framework' data-form-theme='gravity-theme' data-form-index='0' id='gform_wrapper_11' ><div id='gf_11' class='gform_anchor' tabindex='-1'><\/div>\n                        <div class='gform_heading'>\n\t\t\t\t\t\t\t<p class='gform_required_legend'>\u00ab\u00a0<span class=\"gfield_required gfield_required_asterisk\">*<\/span>\u00a0\u00bb indique les champs n\u00e9cessaires<\/p>\n                        <\/div><form method='post' enctype='multipart\/form-data' target='gform_ajax_frame_11' id='gform_11'  action='\/fr\/wp-json\/wp\/v2\/posts\/9937#gf_11' data-formid='11' novalidate><div class='gf_invisible ginput_recaptchav3' data-sitekey='6LcKHvQqAAAAANhsXAUIozVdQgdVqbUaVSmOOEQ8' data-tabindex='0'><input id=\"input_e96277ef775691b32a665d00a36bba25\" class=\"gfield_recaptcha_response\" type=\"hidden\" name=\"input_e96277ef775691b32a665d00a36bba25\" value=\"\"\/><\/div>\n                        <div class='gform-body gform_body'><div id='gform_fields_11' class='gform_fields top_label form_sublabel_below description_below validation_below'><div id=\"field_11_5\" class=\"gfield gfield--type-email gfield--input-type-email gfield_contains_required field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible\"  ><label class='gfield_label gform-field-label' for='input_11_5'>Email<span class=\"gfield_required\"><span class=\"gfield_required gfield_required_asterisk\">*<\/span><\/span><\/label><div class='ginput_container ginput_container_email'>\n                            <input name='input_5' id='input_11_5' type='email' value='' class='large'   placeholder='Email *' aria-required=\"true\" aria-invalid=\"false\"  \/>\n                        <\/div><\/div><div id=\"field_11_1\" class=\"gfield gfield--type-text gfield--input-type-text gfield_contains_required field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible\"  ><label class='gfield_label gform-field-label' for='input_11_1'>Pr\u00e9nom<span class=\"gfield_required\"><span class=\"gfield_required gfield_required_asterisk\">*<\/span><\/span><\/label><div class='ginput_container ginput_container_text'><input name='input_1' id='input_11_1' type='text' value='' class='large'    placeholder='Pr\u00e9nom *' aria-required=\"true\" aria-invalid=\"false\"   \/><\/div><\/div><div id=\"field_11_9\" class=\"gfield gfield--type-text gfield--input-type-text gfield_contains_required field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible\"  ><label class='gfield_label gform-field-label' for='input_11_9'>Nom<span class=\"gfield_required\"><span class=\"gfield_required gfield_required_asterisk\">*<\/span><\/span><\/label><div class='ginput_container ginput_container_text'><input name='input_9' id='input_11_9' type='text' value='' class='large'    placeholder='Nom *' aria-required=\"true\" aria-invalid=\"false\"   \/><\/div><\/div><div id=\"field_11_2\" class=\"gfield gfield--type-text gfield--input-type-text gfield_contains_required field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible\"  ><label class='gfield_label gform-field-label' for='input_11_2'>H\u00f4pital<span class=\"gfield_required\"><span class=\"gfield_required gfield_required_asterisk\">*<\/span><\/span><\/label><div class='ginput_container ginput_container_text'><input name='input_2' id='input_11_2' type='text' value='' class='large'    placeholder='H\u00f4pital *' aria-required=\"true\" aria-invalid=\"false\"   \/><\/div><\/div><div id=\"field_11_13\" class=\"gfield gfield--type-number gfield--input-type-number gfield_contains_required field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible\"  ><label class='gfield_label gform-field-label' for='input_11_13'>Nombre de sites<span class=\"gfield_required\"><span class=\"gfield_required gfield_required_asterisk\">*<\/span><\/span><\/label><div class='ginput_container ginput_container_number'><input name='input_13' id='input_11_13' type='number' step='any'   value='' class='large'    placeholder='Nombre de sites *' aria-required=\"true\" aria-invalid=\"false\"  \/><\/div><\/div><div id=\"field_11_17\" class=\"gfield gfield--type-select gfield--input-type-select gfield--width-full gfield_contains_required field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible\"  ><label class='gfield_label gform-field-label' for='input_11_17'>Country<span class=\"gfield_required\"><span class=\"gfield_required gfield_required_asterisk\">*<\/span><\/span><\/label><div class='ginput_container ginput_container_select'><select name='input_17' id='input_11_17' class='large gfield_select'    aria-required=\"true\" aria-invalid=\"false\" ><option value='Afghanistan' >Afghanistan<\/option><option value='Albania' >Albania<\/option><option value='Algeria' >Algeria<\/option><option value='American Samoa' >American Samoa<\/option><option value='Andorra' >Andorra<\/option><option value='Angola' >Angola<\/option><option value='Anguilla' >Anguilla<\/option><option value='Antarctica' >Antarctica<\/option><option value='Antigua and Barbuda' >Antigua and Barbuda<\/option><option value='Argentina' >Argentina<\/option><option value='Armenia' >Armenia<\/option><option value='Aruba' >Aruba<\/option><option value='Australia' >Australia<\/option><option value='Austria' >Austria<\/option><option value='Azerbaijan' >Azerbaijan<\/option><option value='Bahamas' >Bahamas<\/option><option value='Bahrain' >Bahrain<\/option><option value='Bangladesh' >Bangladesh<\/option><option value='Barbados' >Barbados<\/option><option value='Belarus' >Belarus<\/option><option value='Belgium' >Belgium<\/option><option value='Belize' >Belize<\/option><option value='Benin' >Benin<\/option><option value='Bermuda' >Bermuda<\/option><option value='Bhutan' >Bhutan<\/option><option value='Bolivia' >Bolivia<\/option><option value='Bonaire, Sint Eustatius and Saba' >Bonaire, Sint Eustatius and Saba<\/option><option value='Bosnia and Herzegovina' >Bosnia and Herzegovina<\/option><option value='Botswana' >Botswana<\/option><option value='Bouvet Island' >Bouvet Island<\/option><option value='Brazil' >Brazil<\/option><option value='British Indian Ocean Territory' >British Indian Ocean Territory<\/option><option value='Brunei Darussalam' >Brunei Darussalam<\/option><option value='Bulgaria' >Bulgaria<\/option><option value='Burkina Faso' >Burkina Faso<\/option><option value='Burundi' >Burundi<\/option><option value='Cabo Verde' >Cabo Verde<\/option><option value='Cambodia' >Cambodia<\/option><option value='Cameroon' >Cameroon<\/option><option value='Canada' >Canada<\/option><option value='Cayman Islands' >Cayman Islands<\/option><option value='Central African Republic' >Central African Republic<\/option><option value='Chad' >Chad<\/option><option value='Chile' >Chile<\/option><option value='China' >China<\/option><option value='Christmas Island' >Christmas Island<\/option><option value='Cocos Islands' >Cocos Islands<\/option><option value='Colombia' >Colombia<\/option><option value='Comoros' >Comoros<\/option><option value='Congo' >Congo<\/option><option value='Congo, Democratic Republic of the' >Congo, Democratic Republic of the<\/option><option value='Cook Islands' >Cook Islands<\/option><option value='Costa Rica' >Costa Rica<\/option><option value='Croatia' >Croatia<\/option><option value='Cuba' >Cuba<\/option><option value='Cura\u00e7ao' >Cura\u00e7ao<\/option><option value='Cyprus' >Cyprus<\/option><option value='Czechia' >Czechia<\/option><option value='C\u00f4te d&#039;Ivoire' >C\u00f4te d&#039;Ivoire<\/option><option value='Denmark' >Denmark<\/option><option value='Djibouti' >Djibouti<\/option><option value='Dominica' >Dominica<\/option><option value='Dominican Republic' >Dominican Republic<\/option><option value='Ecuador' >Ecuador<\/option><option value='Egypt' >Egypt<\/option><option value='El Salvador' >El Salvador<\/option><option value='Equatorial Guinea' >Equatorial Guinea<\/option><option value='Eritrea' >Eritrea<\/option><option value='Estonia' >Estonia<\/option><option value='Eswatini' >Eswatini<\/option><option value='Ethiopia' >Ethiopia<\/option><option value='Falkland Islands' >Falkland Islands<\/option><option value='Faroe Islands' >Faroe Islands<\/option><option value='Fiji' >Fiji<\/option><option value='Finland' >Finland<\/option><option value='France' >France<\/option><option value='French Guiana' >French Guiana<\/option><option value='French Polynesia' >French Polynesia<\/option><option value='French Southern Territories' >French Southern Territories<\/option><option value='Gabon' >Gabon<\/option><option value='Gambia' >Gambia<\/option><option value='Georgia' >Georgia<\/option><option value='Germany' >Germany<\/option><option value='Ghana' >Ghana<\/option><option value='Gibraltar' >Gibraltar<\/option><option value='Greece' >Greece<\/option><option value='Greenland' >Greenland<\/option><option value='Grenada' >Grenada<\/option><option value='Guadeloupe' >Guadeloupe<\/option><option value='Guam' >Guam<\/option><option value='Guatemala' >Guatemala<\/option><option value='Guernsey' >Guernsey<\/option><option value='Guinea' >Guinea<\/option><option value='Guinea-Bissau' >Guinea-Bissau<\/option><option value='Guyana' >Guyana<\/option><option value='Haiti' >Haiti<\/option><option value='Heard Island and McDonald Islands' >Heard Island and McDonald Islands<\/option><option value='Holy See' >Holy See<\/option><option value='Honduras' >Honduras<\/option><option value='Hong Kong' >Hong Kong<\/option><option value='Hungary' >Hungary<\/option><option value='Iceland' >Iceland<\/option><option value='India' >India<\/option><option value='Indonesia' >Indonesia<\/option><option value='Iran' >Iran<\/option><option value='Iraq' >Iraq<\/option><option value='Ireland' >Ireland<\/option><option value='Isle of Man' >Isle of Man<\/option><option value='Israel' >Israel<\/option><option value='Italy' >Italy<\/option><option value='Jamaica' >Jamaica<\/option><option value='Japan' >Japan<\/option><option value='Jersey' >Jersey<\/option><option value='Jordan' >Jordan<\/option><option value='Kazakhstan' >Kazakhstan<\/option><option value='Kenya' >Kenya<\/option><option value='Kiribati' >Kiribati<\/option><option value='Korea, Democratic People&#039;s Republic of' >Korea, Democratic People&#039;s Republic of<\/option><option value='Korea, Republic of' >Korea, Republic of<\/option><option value='Kuwait' >Kuwait<\/option><option value='Kyrgyzstan' >Kyrgyzstan<\/option><option value='Lao People&#039;s Democratic Republic' >Lao People&#039;s Democratic Republic<\/option><option value='Latvia' >Latvia<\/option><option value='Lebanon' >Lebanon<\/option><option value='Lesotho' >Lesotho<\/option><option value='Liberia' >Liberia<\/option><option value='Libya' >Libya<\/option><option value='Liechtenstein' >Liechtenstein<\/option><option value='Lithuania' >Lithuania<\/option><option value='Luxembourg' >Luxembourg<\/option><option value='Macao' >Macao<\/option><option value='Madagascar' >Madagascar<\/option><option value='Malawi' >Malawi<\/option><option value='Malaysia' >Malaysia<\/option><option value='Maldives' >Maldives<\/option><option value='Mali' >Mali<\/option><option value='Malta' >Malta<\/option><option value='Marshall Islands' >Marshall Islands<\/option><option value='Martinique' >Martinique<\/option><option value='Mauritania' >Mauritania<\/option><option value='Mauritius' >Mauritius<\/option><option value='Mayotte' >Mayotte<\/option><option value='Mexico' >Mexico<\/option><option value='Micronesia' >Micronesia<\/option><option value='Moldova' >Moldova<\/option><option value='Monaco' >Monaco<\/option><option value='Mongolia' >Mongolia<\/option><option value='Montenegro' >Montenegro<\/option><option value='Montserrat' >Montserrat<\/option><option value='Morocco' >Morocco<\/option><option value='Mozambique' >Mozambique<\/option><option value='Myanmar' >Myanmar<\/option><option value='Namibia' >Namibia<\/option><option value='Nauru' >Nauru<\/option><option value='Nepal' >Nepal<\/option><option value='Netherlands' >Netherlands<\/option><option value='New Caledonia' >New Caledonia<\/option><option value='New Zealand' >New Zealand<\/option><option value='Nicaragua' >Nicaragua<\/option><option value='Niger' >Niger<\/option><option value='Nigeria' >Nigeria<\/option><option value='Niue' >Niue<\/option><option value='Norfolk Island' >Norfolk Island<\/option><option value='North Macedonia' >North Macedonia<\/option><option value='Northern Mariana Islands' >Northern Mariana Islands<\/option><option value='Norway' >Norway<\/option><option value='Oman' >Oman<\/option><option value='Pakistan' >Pakistan<\/option><option value='Palau' >Palau<\/option><option value='Palestine, State of' >Palestine, State of<\/option><option value='Panama' >Panama<\/option><option value='Papua New Guinea' >Papua New Guinea<\/option><option value='Paraguay' >Paraguay<\/option><option value='Peru' >Peru<\/option><option value='Philippines' >Philippines<\/option><option value='Pitcairn' >Pitcairn<\/option><option value='Poland' >Poland<\/option><option value='Portugal' >Portugal<\/option><option value='Puerto Rico' >Puerto Rico<\/option><option value='Qatar' >Qatar<\/option><option value='Romania' >Romania<\/option><option value='Russian Federation' >Russian Federation<\/option><option value='Rwanda' >Rwanda<\/option><option value='R\u00e9union' >R\u00e9union<\/option><option value='Saint Barth\u00e9lemy' >Saint Barth\u00e9lemy<\/option><option value='Saint Helena, Ascension and Tristan da Cunha' >Saint Helena, Ascension and Tristan da Cunha<\/option><option value='Saint Kitts and Nevis' >Saint Kitts and Nevis<\/option><option value='Saint Lucia' >Saint Lucia<\/option><option value='Saint Martin' >Saint Martin<\/option><option value='Saint Pierre and Miquelon' >Saint Pierre and Miquelon<\/option><option value='Saint Vincent and the Grenadines' >Saint Vincent and the Grenadines<\/option><option value='Samoa' >Samoa<\/option><option value='San Marino' >San Marino<\/option><option value='Sao Tome and Principe' >Sao Tome and Principe<\/option><option value='Saudi Arabia' >Saudi Arabia<\/option><option value='Senegal' >Senegal<\/option><option value='Serbia' >Serbia<\/option><option value='Seychelles' >Seychelles<\/option><option value='Sierra Leone' >Sierra Leone<\/option><option value='Singapore' >Singapore<\/option><option value='Sint Maarten' >Sint Maarten<\/option><option value='Slovakia' >Slovakia<\/option><option value='Slovenia' >Slovenia<\/option><option value='Solomon Islands' >Solomon Islands<\/option><option value='Somalia' >Somalia<\/option><option value='South Africa' >South Africa<\/option><option value='South Georgia and the South Sandwich Islands' >South Georgia and the South Sandwich Islands<\/option><option value='South Sudan' >South Sudan<\/option><option value='Spain' >Spain<\/option><option value='Sri Lanka' >Sri Lanka<\/option><option value='Sudan' >Sudan<\/option><option value='Suriname' >Suriname<\/option><option value='Svalbard and Jan Mayen' >Svalbard and Jan Mayen<\/option><option value='Sweden' >Sweden<\/option><option value='Switzerland' >Switzerland<\/option><option value='Syria Arab Republic' >Syria Arab Republic<\/option><option value='Taiwan' >Taiwan<\/option><option value='Tajikistan' >Tajikistan<\/option><option value='Tanzania, the United Republic of' >Tanzania, the United Republic of<\/option><option value='Thailand' >Thailand<\/option><option value='Timor-Leste' >Timor-Leste<\/option><option value='Togo' >Togo<\/option><option value='Tokelau' >Tokelau<\/option><option value='Tonga' >Tonga<\/option><option value='Trinidad and Tobago' >Trinidad and Tobago<\/option><option value='Tunisia' >Tunisia<\/option><option value='Turkmenistan' >Turkmenistan<\/option><option value='Turks and Caicos Islands' >Turks and Caicos Islands<\/option><option value='Tuvalu' >Tuvalu<\/option><option value='T\u00fcrkiye' >T\u00fcrkiye<\/option><option value='US Minor Outlying Islands' >US Minor Outlying Islands<\/option><option value='Uganda' >Uganda<\/option><option value='Ukraine' >Ukraine<\/option><option value='United Arab Emirates' >United Arab Emirates<\/option><option value='United Kingdom' >United Kingdom<\/option><option value='United States' selected='selected'>United States<\/option><option value='Uruguay' >Uruguay<\/option><option value='Uzbekistan' >Uzbekistan<\/option><option value='Vanuatu' >Vanuatu<\/option><option value='Venezuela' >Venezuela<\/option><option value='Viet Nam' >Viet Nam<\/option><option value='Virgin Islands, British' >Virgin Islands, British<\/option><option value='Virgin Islands, U.S.' >Virgin Islands, U.S.<\/option><option value='Wallis and Futuna' >Wallis and Futuna<\/option><option value='Western Sahara' >Western Sahara<\/option><option value='Yemen' >Yemen<\/option><option value='Zambia' >Zambia<\/option><option value='Zimbabwe' >Zimbabwe<\/option><option value='\u00c5land Islands' >\u00c5land Islands<\/option><option value='Other' >Other<\/option><\/select><\/div><\/div><div id=\"field_11_6\" class=\"gfield gfield--type-phone gfield--input-type-phone gfield_contains_required field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible\"  ><label class='gfield_label gform-field-label' for='input_11_6'>T\u00e9l\u00e9phone<span class=\"gfield_required\"><span class=\"gfield_required gfield_required_asterisk\">*<\/span><\/span><\/label><div class='ginput_container ginput_container_phone'><input name='input_6' id='input_11_6' type='tel' value='' class='large'  placeholder='T\u00e9l\u00e9phone *' aria-required=\"true\" aria-invalid=\"false\"   \/><\/div><\/div><div id=\"field_11_14\" class=\"gfield gfield--type-textarea gfield--input-type-textarea gfield--width-full field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible\"  ><label class='gfield_label gform-field-label' for='input_11_14'>Questions ou commentaires<\/label><div class='ginput_container ginput_container_textarea'><textarea name='input_14' id='input_11_14' class='textarea large'    placeholder='Questions ou commentaires'  aria-invalid=\"false\"   rows='10' cols='50'><\/textarea><\/div><\/div><div id=\"field_11_7\" class=\"gfield gfield--type-hidden gfield--input-type-hidden gform_hidden field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible\"  ><div class='ginput_container ginput_container_text'><input name='input_7' id='input_11_7' type='hidden' class='gform_hidden'  aria-invalid=\"false\" value='216.73.216.147' \/><\/div><\/div><div id=\"field_11_8\" class=\"gfield gfield--type-hidden gfield--input-type-hidden gform_hidden field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible\"  ><div class='ginput_container ginput_container_text'><input name='input_8' id='input_11_8' type='hidden' class='gform_hidden'  aria-invalid=\"false\" value='' \/><\/div><\/div><div id=\"field_11_10\" class=\"gfield gfield--type-hidden gfield--input-type-hidden gform_hidden field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible\"  ><div class='ginput_container ginput_container_text'><input name='input_10' id='input_11_10' type='hidden' class='gform_hidden'  aria-invalid=\"false\" value='' \/><\/div><\/div><div id=\"field_11_15\" class=\"gfield gfield--type-hidden gfield--input-type-hidden gfield--width-full gform_hidden field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible\"  ><div class='ginput_container ginput_container_text'><input name='input_15' id='input_11_15' type='hidden' class='gform_hidden'  aria-invalid=\"false\" value='' \/><\/div><\/div><\/div><\/div>\n        <div class='gform-footer gform_footer top_label'> <input type='submit' id='gform_submit_button_11' class='gform_button button' onclick='gform.submission.handleButtonClick(this);' data-submission-type='submit' value='Suivant'  \/> <input type='hidden' name='gform_ajax' value='form_id=11&amp;title=&amp;description=&amp;tabindex=0&amp;theme=gravity-theme&amp;hash=0e221ad7fc865118efa37052fc2ace42' \/>\n            <input type='hidden' class='gform_hidden' name='gform_submission_method' data-js='gform_submission_method_11' value='iframe' \/>\n            <input type='hidden' class='gform_hidden' name='gform_theme' data-js='gform_theme_11' id='gform_theme_11' value='gravity-theme' \/>\n            <input type='hidden' class='gform_hidden' name='gform_style_settings' data-js='gform_style_settings_11' id='gform_style_settings_11' value='' \/>\n            <input type='hidden' class='gform_hidden' name='is_submit_11' value='1' \/>\n            <input type='hidden' class='gform_hidden' name='gform_submit' value='11' \/>\n            \n            <input type='hidden' class='gform_hidden' name='gform_currency' data-currency='AUD' value='GlW+qqVa2ROUPp2KzIqE5iSMTasB8f0EvycVQi+RPkJG1uVKmtm+dK26T1h6U5ls+cA3EIPzsijfM2rLez+mhrhylUM3wtmQJtoG0z2R4\/gfJbE=' \/>\n            <input type='hidden' class='gform_hidden' name='gform_unique_id' value='' \/>\n            <input type='hidden' class='gform_hidden' name='state_11' value='["{\"17\":[\"3df87c280d1c21a7c2ae4bcf00e36026\",\"cf5e34b89a79e6e19c0ac67697e0b55a\",\"d11240785e9943acd8653b47dca1b7dd\",\"d2827ae89f590d9dc744d3731a36d24b\",\"c839fae9346ad7e2b349bcbd119641a0\",\"77fcaf901765d5761f169843d6682e6b\",\"d3db818dcc8bb1c71308ee513193b357\",\"54904f55412175a899f28a36f4ba2e57\",\"b6c97e33c343c6d84cb7abd2b8403a7a\",\"6b3a233a191594f6788205ec24113e14\",\"aec158947008a970ae76e9548cb649f8\",\"1012b8fce848ba82ed60b56a4e8b685b\",\"054841734a7a079d1bbf7cb55fac1b2f\",\"f15d74172889199be3a764af3d1247c4\",\"44c4274afa3f709c95fd1e8a8568d646\",\"ef6b3538638fe99f5dfd0e8f201debcf\",\"dbd313836f7a32d2a42914f63940789c\",\"aa88e955e7c4294b5e65fd4daf79ade4\",\"9f436bc68308734f081577cc37f677fb\",\"0c7a14df478b0a9e34192be1c4371791\",\"98de6780e3687feee4d7b2aaa43195c5\",\"ecfe2efc2ad8724e1b6f7bd702c76181\",\"4d936f8cd3eaf761a332d0ff2b730610\",\"fdb6d7092f8829d404155d8b7a6dfe41\",\"7b77ce9ef3813787252d114ce2f3ba09\",\"ecf1b59d267956d1f6dd5a358a557437\",\"db1d8795a79877fef2df2591bde7e28d\",\"4ec6dee98d353eb541848d00a67e5749\",\"1b4686f68dac001579fec3472128d56c\",\"1809db6660b049b73b13c7276931c282\",\"23908cc0cb55daaf63944e96aa902f23\",\"3539cf09639b0ce64e8d896d5312d70a\",\"53ca876f4abf0ca169c91b6c32ae74aa\",\"6ec2d8591c947517d4aa407709f5d4f4\",\"63770d43d99742df546c8a6d31e292aa\",\"ce1cd125d9c4245d971298d5beb392b3\",\"67045f0872b6c5ba71e0a7f27a003bf9\",\"4b7de527ab1cab4e0409c60cf917aeb9\",\"051e3f8f6216bb04a8a9e2bbe4f10abe\",\"2fd9c50677e62ae3c7dd009878775274\",\"696d2c04e54edb16d6bbb70c7bc81ecc\",\"08bde47c3440b8d7464632e5c7cd6189\",\"75cf3285f9127e4a3ebc4d98e64c83f1\",\"1c9baf9a0f9d11b593d49b7c6c06b681\",\"b75c15b3e9736e3c371606aa7134c352\",\"38829e0ab84f9c8e935e14079c069cb9\",\"119fbc7dd967ebc66e90a7f9b936eb96\",\"8b14432074f9afacdc3eca965cc6fda3\",\"001e661b37b9c63b2ac16f3bcb4a6ba9\",\"41a12befa91e677db9fe325b4ce0fbd5\",\"36b0bec9d034a7876661fe4f657a254e\",\"301dbe4dfb70a28c4a2b933f0d280b78\",\"3a44cd32ab9a7b4781240a4e07874841\",\"22738b43224697e36cf3c9559d67d94c\",\"8d89de9ef1b9714a3b59d183230b6fca\",\"92b9e9b3b12c37908ca53544eab76531\",\"f6e00a50863e79fe261cedefd13aaae1\",\"6a4ae37e862252f3343dee45a9b641f1\",\"6ffa2b06400345debb109692d583dd7e\",\"a1b188928cf1f900f3098ff0efe0b352\",\"fdc9e4dc1d3f0972cb2768f0b7c21739\",\"f178f530c4d026196a5d15c98ba0a56c\",\"624d4d10765f04aa903e78b68e9fae3d\",\"c296efe5e0c75227d5ef370e2681ea03\",\"6b7ffcd0f0539ed783c87e858901f6f0\",\"c282d86ba3cffe3fb9501eb94a8b3514\",\"c900551f6f398548afbfadd945c54a60\",\"f9377297572ab21b3aa993da4f364c48\",\"c84075f337c6e3ba02275e224d23b83e\",\"ef6ca74c3ec2c7a495f19327f08b0ee2\",\"e05595a94a6d87244309c8a66c5ace29\",\"6a9e08e477cf66c464850f52a0e11aec\",\"3f4035b51e9d016a74a5724dda68249f\",\"f6b034c03bda666462f4f2238d31ef52\",\"5a81ce0f305dd0a4f4a4a2ad50747d27\",\"7d0e68907be1d06af8b8ef25dc50292b\",\"5ac5a3791e982ecb54811e086f155d4f\",\"c8bcf3caffb5531b36cc0148b8a5a8ff\",\"c071a926ee2a54fd399d2b9c65ece10f\",\"1bbc6e71b577b9e35bd3f8e63e8b9e40\",\"2aea7cb55235ebfd525caec8a631b6b0\",\"2e4bd5afbdd73410e2c8921bbbc484e0\",\"415d94b022bcbbb0f9b3b77cb38041b5\",\"20e63f5e97e210644068eca7f06aada4\",\"77a735a2ee93c96de4af4e6edddb2a1c\",\"af4f34d38475a49378ddbdc773cb9ff1\",\"fb0dee94d4a89b3980945988230a0f28\",\"899d6edaf35c16a3bb63307b0e29cde6\",\"d6cb36e6a2f0027d33717c0111635845\",\"ce4d8bcb35a130d961744dfff517bbd8\",\"e8136f91019a72254f1b0b32da80dd3b\",\"81c19c9535668501bf71c14e1b3ca655\",\"edf4b4273414d7e03806e9e5afa59841\",\"3e457b949f8d5e9cf9837378f114ffc6\",\"4f7c56607604d741dbd8027c227d2743\",\"0d3360b8dc8daaf11c07c033fa003493\",\"38d959d3eb02303259bc8ac02a14b4a0\",\"d5e6b46ae242da3f086c10ebeea38f5a\",\"c08adb7a9435c1261b7f1ea80b99fecd\",\"d2f40cc0654a1ccf775d9c69cc308154\",\"1850850dae38c6158d746c7d866ec80d\",\"6d09e5173086f32d5747c42bcd27886c\",\"27bd7c25017421ba0044428340fd1fea\",\"9fe7b1bc1c195ca71c7d6d5e19b14ebb\",\"ac59afa6aa32103a80995a63e774ead8\",\"fdd31f4e58ea9f713d8142a03d2a3e7f\",\"2fde86115b4f8d316b24a649db2038d5\",\"2c0bb59716075b2df4b8c1ba208eeb98\",\"5198fa45d13332b11031fe3b83d95194\",\"9cdb21a9e4d98ff2f7394b8d839b846a\",\"6117face948569facdb423146fd93f98\",\"cf4c5e073c84aefbfb54149e46967ce5\",\"2532dd1ef58267264849f69ef66c0802\",\"41974d9b877c2b183f5cc7aa07f11750\",\"1db5782d616ac3ef26682fcb4bb27257\",\"d01ebc640eb372b4668e3ebe70af0dd7\",\"d5b8e3f85ae0339e7af91fd9de49121c\",\"fcf8ac4b8c9d0cfdf790908946169645\",\"dae4194830502240b75a36fe411d99a0\",\"99e6b221e5bde5b588471f529771a34e\",\"2b9d84d64694034346a7bc15ae5196d4\",\"9da7b7bf39ade01d826bb22b40125908\",\"d289ae941f9612b1d803517da0e057ef\",\"735269917fd7ef75017826e55be1b9ea\",\"778a09f597c77f882559379ca04d7143\",\"96c497fe5b76051e996b92000a5e4798\",\"24d3ad0d667569639b0e60a0054002de\",\"fc2cb9e1dbb5dea7d64fa18567360449\",\"a0e7c18718ae137609df5817a38dc1c6\",\"e83a8eb848a5092a7b53d001bdde8a97\",\"3a4d24a77cb9871fd899158f43463bc8\",\"214cad8cb5c913d2792318d3b77c6550\",\"7f34d03a1b7642dcbb86fd70eb022442\",\"d08e48e393963fbc15df1d8f730628e5\",\"a591410f151244df7e2d2fe2cef45bc8\",\"c472123002d19f2a6115dee09cebe72d\",\"c3ce0d3a891ac6096591d97662af6892\",\"b89b7ff2e19b5f8bbe8d1ce1d56d75a8\",\"6aeee250bc3e6d6a9a8e59c5dcd60f35\",\"6dae4919bf6eea3cb4d8f8a52a5ec88c\",\"2eaa43c49e0803be37f42fa9e1f7e7de\",\"d2d35e1d7b97b4e4f35ab005c34890f8\",\"9dff34df24d3d02ce60ff4cd002d51cd\",\"ddc27953f111b15cb7142a22686858e4\",\"7f669e0b72d185f57f6a8ffc11a7260f\",\"9b1fc78525fabedec9b5f004d27f1028\",\"87b705b2c8e3a06ef6b76813ef2ff59e\",\"25d664354c9ec67c02e9fcefbf36eff4\",\"dcf75ddba13b8f5f0b3a2a9cae5ccac7\",\"5114214f86d89b52cdf90e63629f9927\",\"12278e1df2639fc0872fc8e8f8510dee\",\"d9a4215bc8f056e0bc9ccd27c8b7ca2c\",\"baebc1429e2e4ca740bece0635c1650b\",\"d134541dc811397b11bd6b009096645b\",\"0b4f8ca198de30a26c011b20b28dcdc5\",\"ea2a1e9d67f88dc67a26dc66633fbacc\",\"7e7439a2842e852f0bd3c17e2c4f2a65\",\"308116c4659d17507e0175ffcfbe325a\",\"fe06e1d5fecd87c5915e5a6395d9dc1a\",\"df9f9637ccfd2f6d33a2834a79d234b0\",\"c716e743ff348f4e46921f064bda63ca\",\"90d309a62505e8016032eb34007cc372\",\"53a8a8bb870e7467cf12bf3c166ace15\",\"11e0cb57866aee3224638a863f4bea6d\",\"98860e683e95759bfc7cdb5aa9d12f24\",\"b1cc291a30fcf82cf28e19d0c694d9b6\",\"16a3504bbdffc75ab4b5df0885215042\",\"f646ef3c70c8bae1df57d7aa9e1dc457\",\"0f53f89f64329d8706450121a53755dd\",\"9c3b3044d96ff8c7b3e51210500a8d8c\",\"f1742087fafb9dbb74ce75ed37f2d4b5\",\"75bbe46d1ef956d017c8ec43d4773c68\",\"e0a355026afbb21d6412767836104f14\",\"a197c9c681eb4211c1c4663424f8775d\",\"33491883079e66780591ca529205678b\",\"cc5face165928cbde048de418d1aa0a5\",\"350947f7fb50fb440d94a78bd9904f4e\",\"9f17bbcad30dbd995d9ca5bd31dad5c5\",\"c0a73acdd31de759352f7ffcea9c773b\",\"5cdd24dbcf964edf3946dcbd74473cab\",\"e7d88d802e97b4bfa39ac912cdfc6189\",\"c6b7fe9bf76ba1cb17649c37a4ef990c\",\"a4c748359bdae8fa87b1905814fb19d7\",\"8989b676ab34931cbeff2bdbf137332a\",\"a12b0dd1f87190ac5e4efacfc1eebb70\",\"b69e9c5981f228967d2a43d1f7211e0c\",\"dff954fc920e39276e75db2ff65e58a1\",\"571fc86640aaa799c2281308efe88273\",\"27ad205c7260735d16c59865b35353a1\",\"1b762e64b52c8accf969ad98a964ed2a\",\"777af85e70422d88bf9f2b9dc7274ffa\",\"8685dfb90709c8221d5c551cc31e86ad\",\"63eed47c13e7c162d816aa633abf1307\",\"db0abbb04864acc7090c5eaf87cdaf75\",\"99a9c685e3c95ee7a49dfb5a379d2640\",\"6b16dfb7459d2bebe35059ccd521b1dc\",\"39d96395ea1b70e814397e1e78eecc9a\",\"bf7ee6606a627f1c3a92ecd1a160c8d8\",\"eb276e42c0438321df32fe06b525fe67\",\"4aff5617ef622ba0a226dc6cdb5c6da1\",\"8c501224090064346422ed80e037c382\",\"30735d0b719719eda82b73229dd60764\",\"47016ba59a47f306c8063fcd126aec99\",\"b02936dbb5727d5370180bc237cc5539\",\"40fb1bd78b166fee9df6572118788cf6\",\"9051b6b3ae83f55ac26c159291c15a03\",\"3ba574c19cf465bf47d9e35594e123a0\",\"c0e85cbca5a88c9ba0d004f146eaebcc\",\"d7b664df9af691e8cec11cfb6f41c374\",\"2285549645745150d986c1c3270bb872\",\"adcc5e433aa610eb3576afb6ee05ade5\",\"6521d84a5e22667e469ed38bc056d75b\",\"68a4459ed1a174f008cf4cbe2e053108\",\"56b0b4f5c3d1f10d6bded646afc9a40f\",\"925ec36a421c0e98f621f81e95721a53\",\"81d3ec8d8db76754195feba5bf09bd3f\",\"b6d1451a8d5fe5f34e1320f6a762f71f\",\"a1aac8c4b81e004d7bfc53e02b32b6c8\",\"dfb89a48795ba2591fdeea021e3b97f0\",\"74acf72ca5c0c212d87d08aefaf5e953\",\"7aee0e183da9887f7b9239d3c17533da\",\"a4f0efbcc4ab58eed32b145d63ca71b2\",\"7bf88c105d39f52e578d8301d843416a\",\"3354ee1b5e0126aec3ed3aae8ba4c0f1\",\"bbc29df3349f60d7c85045632cc36c23\",\"1e3c030debe1422480aad7c00d8031e7\",\"e309af6598e3324f0e20a71ec4385910\",\"b9703f4a583a9df7459f09fb4ad01f0b\",\"2e87dac789e688b292b0b3524039b59d\",\"ed3cfbf4badbdc24f00f8e5e907d0940\",\"ba473aac871744039e93a67a7a6c711c\",\"9cdbd621448fc113c9ccd73b9401be9a\",\"6e9282546a9000f982c5d6774c6c9aec\",\"844f7a09dc1400a0c48fcdb843ab6a34\",\"b9d680f8505546702007974423ce3981\",\"048ca1813fcb79651c77caf7ef1d8576\",\"cdf56439576934b351614c4128e4b6c6\",\"72754cfa8d00166ae42edc5ba464bbd5\",\"2be114b9de3534b93960035ad30908f6\",\"ac905a938928eb744bfe7c8afa2f85ba\",\"030ef325054a3d31f6e307ecbc0a3063\",\"cff075737a334a8674b44e799d5de03d\",\"96e53b862ee233cb22e0491d352a23a0\",\"c4c5c8248d0e1134f9fa83df24c54223\",\"04611d4eeb1a3388f273ce26ba1a9b7b\",\"0fe0ce0d8b14e41b049373b4b8b6297b\",\"4d26dc7e8775e88af3d810b4eeb2d97a\",\"a28f73789014df94781ff4d747685e6e\",\"b8bcb12b33130601a2c84846c03ea0f4\",\"dd4020eb535aff2abb49b93d077556af\"]}","46fec049c762c72163039b2e0ec36ac9"]' \/>\n            <input type='hidden' autocomplete='off' class='gform_hidden' name='gform_target_page_number_11' id='gform_target_page_number_11' value='0' \/>\n            <input type='hidden' autocomplete='off' class='gform_hidden' name='gform_source_page_number_11' id='gform_source_page_number_11' value='1' \/>\n            <input type='hidden' name='gform_field_values' value='' \/>\n            \n        <\/div>\n                        <\/form>\n                        <\/div>\n\t\t                <iframe style='display:none;width:0px;height:0px;' src='about:blank' name='gform_ajax_frame_11' id='gform_ajax_frame_11' title='Cette iframe contient la logique n\u00e9cessaire pour manipuler Gravity Forms avec Ajax.'><\/iframe>\n\t\t                <script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n gform.initializeOnLoaded( function() {gformInitSpinner( 11, 'https:\/\/doseme-rx.com\/wp-content\/plugins\/gravityforms\/images\/spinner.svg', true );jQuery('#gform_ajax_frame_11').on('load',function(){var contents = jQuery(this).contents().find('*').html();var is_postback = contents.indexOf('GF_AJAX_POSTBACK') >= 0;if(!is_postback){return;}var form_content = jQuery(this).contents().find('#gform_wrapper_11');var is_confirmation = jQuery(this).contents().find('#gform_confirmation_wrapper_11').length > 0;var is_redirect = contents.indexOf('gformRedirect(){') >= 0;var is_form = form_content.length > 0 && ! is_redirect && ! is_confirmation;var mt = parseInt(jQuery('html').css('margin-top'), 10) + parseInt(jQuery('body').css('margin-top'), 10) + 100;if(is_form){jQuery('#gform_wrapper_11').html(form_content.html());if(form_content.hasClass('gform_validation_error')){jQuery('#gform_wrapper_11').addClass('gform_validation_error');} else {jQuery('#gform_wrapper_11').removeClass('gform_validation_error');}setTimeout( function() { \/* delay the scroll by 50 milliseconds to fix a bug in chrome *\/ jQuery(document).scrollTop(jQuery('#gform_wrapper_11').offset().top - mt); }, 50 );if(window['gformInitDatepicker']) {gformInitDatepicker();}if(window['gformInitPriceFields']) {gformInitPriceFields();}var current_page = jQuery('#gform_source_page_number_11').val();gformInitSpinner( 11, 'https:\/\/doseme-rx.com\/wp-content\/plugins\/gravityforms\/images\/spinner.svg', true );jQuery(document).trigger('gform_page_loaded', [11, current_page]);window['gf_submitting_11'] = false;}else if(!is_redirect){var confirmation_content = jQuery(this).contents().find('.GF_AJAX_POSTBACK').html();if(!confirmation_content){confirmation_content = contents;}jQuery('#gform_wrapper_11').replaceWith(confirmation_content);jQuery(document).scrollTop(jQuery('#gf_11').offset().top - mt);jQuery(document).trigger('gform_confirmation_loaded', [11]);window['gf_submitting_11'] = false;wp.a11y.speak(jQuery('#gform_confirmation_message_11').text());}else{jQuery('#gform_11').append(contents);if(window['gformRedirect']) {gformRedirect();}}jQuery(document).trigger(\"gform_pre_post_render\", [{ formId: \"11\", currentPage: \"current_page\", abort: function() { this.preventDefault(); } }]);        if (event && event.defaultPrevented) {                return;        }        const gformWrapperDiv = document.getElementById( \"gform_wrapper_11\" );        if ( gformWrapperDiv ) {            const visibilitySpan = document.createElement( \"span\" );            visibilitySpan.id = \"gform_visibility_test_11\";            gformWrapperDiv.insertAdjacentElement( \"afterend\", visibilitySpan );        }        const visibilityTestDiv = document.getElementById( \"gform_visibility_test_11\" );        let postRenderFired = false;        function triggerPostRender() {            if ( postRenderFired ) {                return;            }            postRenderFired = true;            gform.core.triggerPostRenderEvents( 11, current_page );            if ( visibilityTestDiv ) {                visibilityTestDiv.parentNode.removeChild( visibilityTestDiv );            }        }        function debounce( func, wait, immediate ) {            var timeout;            return function() {                var context = this, args = arguments;                var later = function() {                    timeout = null;                    if ( !immediate ) func.apply( context, args );                };                var callNow = immediate && !timeout;                clearTimeout( timeout );                timeout = setTimeout( later, wait );                if ( callNow ) func.apply( context, args );            };        }        const debouncedTriggerPostRender = debounce( function() {            triggerPostRender();        }, 200 );        if ( visibilityTestDiv && visibilityTestDiv.offsetParent === null ) {            const observer = new MutationObserver( ( mutations ) => {                mutations.forEach( ( mutation ) => {                    if ( mutation.type === 'attributes' && visibilityTestDiv.offsetParent !== null ) {                        debouncedTriggerPostRender();                        observer.disconnect();                    }                });            });            observer.observe( document.body, {                attributes: true,                childList: false,                subtree: true,                attributeFilter: [ 'style', 'class' ],            });        } else {            triggerPostRender();        }    } );} ); \n\/* ]]> *\/\n<\/script>\n                    \r\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">References<\/h2>\n\n\n\n<ol class=\"wp-block-list\" type=\"1\">\n<li>Imani S, Fitzgerald DA, Robinson PD, et al. Personalized tobramycin dosing in children with cystic fibrosis: A comparative clinical evaluation of log-linear and Bayesian methods. J Antimicrob Chemother. 2022;77(12):3358-3366. doi:<a href=\"https:\/\/doi.org\/10.1093\/jac\/dkac324\">10.1093\/jac\/dkac324<\/a><\/li>\n\n\n\n<li>About cystic fibrosis. Cystic Fibrosis Foundation. (n.d.). Retrieved February 3, 2023 from <a href=\"https:\/\/www.cff.org\/intro-cf\/about-cystic-fibrosis\">https:\/\/www.cff.org\/intro-cf\/about-cystic-fibrosis<\/a>&nbsp;<\/li>\n\n\n\n<li>Sanders DB, Fink AK. Background and Epidemiology. Pediatr Clin North Am. 2016;63(4):567-584. <a href=\"https:\/\/doi.org\/10.1016\/j.pcl.2016.04.001\">https:\/\/doi.org\/10.1016\/j.pcl.2016.04.001<\/a>&nbsp;<\/li>\n\n\n\n<li>U.S. National Library of Medicine. (n.d.). CFTR gene: CF transmembrane conductance regulator. MedlinePlus. Retrieved February 2, 2023 from <a href=\"https:\/\/medlineplus.gov\/genetics\/gene\/cftr\/\">https:\/\/medlineplus.gov\/genetics\/gene\/cftr\/<\/a>&nbsp;<\/li>\n\n\n\n<li>Sanders DB, Bittner RC, Rosenfeld M, et al. Pulmonary exacerbations are associated with subsequent FEV1 decline in both adults and children with cystic fibrosis. Pediatr Pulmonol. 2011;46(4):393-400. doi:<a href=\"https:\/\/doi.org\/10.1002\/ppul.21374\">10.1002\/ppul.21374<\/a><\/li>\n\n\n\n<li>Goss CH. Acute pulmonary exacerbations in cystic fibrosis. Semin Respir Crit Care Med. 2019;40(6):792-803. <a href=\"https:\/\/doi.org\/10.1055\/s-0039-1697975\">https:\/\/doi.org\/10.1055\/s-0039-1697975<\/a>&nbsp;&nbsp;<\/li>\n\n\n\n<li>Castellani C, Duff AJA, Bell SC, et al. ECFS best practice guidelines: The 2018 revision. J Cyst Fibros. 2018;17(2):153-178. <a href=\"https:\/\/doi.org\/10.1016\/j.jcf.2018.02.006\">https:\/\/doi.org\/10.1016\/j.jcf.2018.02.006<\/a>.<\/li>\n\n\n\n<li>Filkins LM, O&rsquo;Toole GA. Cystic fibrosis lung infections: Polymicrobial, complex, and hard to treat. PLoS Pathog. 2015;11(12):e1005258. <a href=\"https:\/\/doi.org\/10.1371\/journal.ppat.1005258\">https:\/\/doi.org\/10.1371\/journal.ppat.1005258<\/a><\/li>\n\n\n\n<li>Emerson J, Rosenfeld M, McNamara S, et al. <em>Pseudomonas aeruginosa<\/em> and other predictors of mortality and morbidity in young children with cystic fibrosis. Pediatr Pulmonol. 2002;34(2):91-100. doi:<a href=\"https:\/\/doi.org\/10.1002\/ppul.10127\">https:\/\/doi.org\/10.1002\/ppul.10127<\/a><\/li>\n\n\n\n<li>Flume PA, Mogayzel PJ Jr, Robinson KA, et al. Cystic fibrosis pulmonary guidelines: Treatment of pulmonary exacerbations. Am J Respir Crit Care Med. 2009;180(9):802-808. doi:<a href=\"https:\/\/doi.org\/10.1164\/rccm.200812-1845pp\">https:\/\/doi.org\/10.1164\/rccm.200812-1845PP<\/a><\/li>\n\n\n\n<li>Horrevorts AM, Driessen OM, Michel MF, Kerrebijn KF. Pharmacokinetics of antimicrobial drugs in cystic fibrosis. Aminoglycoside antibiotics. Chest. 1988;94(2 Suppl):120S-125S.&nbsp;<\/li>\n\n\n\n<li>Akkerman-Nijland AM, Akkerman OW, Grasmeijer F, et al. The pharmacokinetics of antibiotics in cystic fibrosis. Expert Opin Drug Metab Toxicol. 2021;17:1:53-68. <a href=\"https:\/\/doi.org\/10.1080\/17425255.2021.1836157\">https:\/\/doi.org\/10.1080\/17425255.2021.1836157<\/a><\/li>\n\n\n\n<li>Mendelman PM, Smith AL, Levy J, et al. Aminoglycoside penetration, inactivation, and efficacy in cystic fibrosis sputum. Am Rev Respir Dis. 1985;132(4):761-765. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3931522\/\">https:\/\/doi.org\/10.1164\/arrd.1985.132.4.761<\/a><\/li>\n\n\n\n<li>Touw DJ. Clinical pharmacokinetics of antimicrobial drugs in cystic fibrosis. Pharm World Sci. 1998;20(4):149-160. doi:<a href=\"https:\/\/doi.org\/10.1023\/a:1008634911114\">https:\/\/doi.org\/10.1023\/a:1008634911114<\/a><\/li>\n\n\n\n<li>Galiniak RM, Biesiadecki S, Gala-B\u0142\u0105dzi\u0144ska A. Renal function in patients with cystic fibrosis: A single-center study. Int J Envrion Res Public Health. 2022;19(9):5454. <a href=\"https:\/\/doi.org\/10.3390\/ijerph19095454\">https:\/\/doi.org\/10.3390\/ijerph19095454<\/a><\/li>\n\n\n\n<li>Prayle A, Watson A, Fortnum H, Smyth A. Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis. Thorax. 2010;65(7):654-658. doi:<a href=\"https:\/\/doi.org\/10.1136\/thx.2009.131532\">https:\/\/doi.org\/10.1136\/thx.2009.131532<\/a><\/li>\n\n\n\n<li>Jawie\u0144 W. Searching for an optimal AUC estimation method: A never-ending task?<br>J Pharmacokinet Pharmacodyn. 2014;41(6):655-673. <a href=\"https:\/\/doi.org\/10.1007\/s10928-014-9392-y\">https:\/\/doi.org\/10.1007\/s10928-014-9392-y<\/a>&nbsp;<\/li>\n\n\n\n<li>Barras MA, Serisier D, Hennig S, et al. Bayesian estimation of tobramycin exposure in patients with cystic fibrosis. Antimicrob Agents Chemother. 2016; 60(11):6698-6702. <a href=\"https:\/\/doi.org\/10.1128\/AAC.01131-16\">https:\/\/doi.org\/10.1128\/AAC.01131-16<\/a>&nbsp;<\/li>\n\n\n\n<li>Aminoglycosides: Recommendations for use, dosing and monitoring. Government of South Australia. 2020. Retrieved from: <a href=\"https:\/\/www.sahealth.sa.gov.au\/wps\/wcm\/connect\/public+content\/sa+health+internet\/clinical+resources\/clinical+programs+and+practice+guidelines\/medicines+and+drugs\/antimicrobial+guidelines\/antimicrobial+guidelines\">https:\/\/www.sahealth.sa.gov.au\/wps\/wcm\/connect\/public+content\/sa+health+internet\/clinical+resources\/clinical+programs+and+practice+guidelines\/medicines+and+drugs\/antimicrobial+guidelines\/antimicrobial+guidelines<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Find out how tobramycin dosing with DoseMeRx reduces labs, saves time and money <\/p>\n","protected":false},"author":32,"featured_media":9951,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8,14,57,26],"tags":[38,43,37],"article-type":[49],"class_list":["post-9937","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-media","category-success","category-tobramycin","category-vancomycin","tag-blog","tag-tobramycin","tag-vancomycin-dosing"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Bayesian Dosing of Tobramycin Outperforms Other Personalized Dosing Strategies at Pediatric Hospital &#8226; DoseMeRx<\/title>\n<meta name=\"description\" content=\"Find out how Bayesian dosing of tobramycin with DoseMeRx reduces labs, saves time and money at The Children&#039;s Hospital at Westmead, Australia\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bayesian Dosing of Tobramycin Outperforms Other Personalized Dosing Strategies at Pediatric Hospital &#8226; DoseMeRx\" \/>\n<meta property=\"og:description\" content=\"Find out how Bayesian dosing of tobramycin with DoseMeRx reduces labs, saves time and money at The Children&#039;s Hospital at Westmead, Australia\" \/>\n<meta property=\"og:url\" content=\"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies\" \/>\n<meta property=\"og:site_name\" content=\"DoseMeRx\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/DoseMeApp\/\" \/>\n<meta property=\"article:published_time\" content=\"2023-03-15T14:36:31+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-21T19:46:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/iStock-894463832_ped-pic.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2119\" \/>\n\t<meta property=\"og:image:height\" content=\"1414\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Brit Vezina\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@DoseMeApp\" \/>\n<meta name=\"twitter:site\" content=\"@DoseMeApp\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Brit Vezina\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"10 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Bayesian Dosing of Tobramycin Outperforms Other Personalized Dosing Strategies at Pediatric Hospital &#8226; DoseMeRx","description":"Find out how Bayesian dosing of tobramycin with DoseMeRx reduces labs, saves time and money at The Children's Hospital at Westmead, Australia","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies","og_locale":"fr_FR","og_type":"article","og_title":"Bayesian Dosing of Tobramycin Outperforms Other Personalized Dosing Strategies at Pediatric Hospital &#8226; DoseMeRx","og_description":"Find out how Bayesian dosing of tobramycin with DoseMeRx reduces labs, saves time and money at The Children's Hospital at Westmead, Australia","og_url":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies","og_site_name":"DoseMeRx","article_publisher":"https:\/\/www.facebook.com\/DoseMeApp\/","article_published_time":"2023-03-15T14:36:31+00:00","article_modified_time":"2025-01-21T19:46:12+00:00","og_image":[{"width":2119,"height":1414,"url":"https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/iStock-894463832_ped-pic.jpg","type":"image\/jpeg"}],"author":"Brit Vezina","twitter_card":"summary_large_image","twitter_creator":"@DoseMeApp","twitter_site":"@DoseMeApp","twitter_misc":{"\u00c9crit par":"Brit Vezina","Dur\u00e9e de lecture estim\u00e9e":"10 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies#article","isPartOf":{"@id":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies"},"author":{"name":"Brit Vezina","@id":"https:\/\/doseme-rx.com\/fr#\/schema\/person\/405846f0fce6edef593fe453fe3733dc"},"headline":"Bayesian Dosing of Tobramycin Outperforms Other Personalized Dosing Strategies at Pediatric Hospital","datePublished":"2023-03-15T14:36:31+00:00","dateModified":"2025-01-21T19:46:12+00:00","mainEntityOfPage":{"@id":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies"},"wordCount":2086,"image":{"@id":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies#primaryimage"},"thumbnailUrl":"https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/iStock-894463832_ped-pic.jpg","keywords":["Blog","Tobramycin","Vancomycin Dosing"],"articleSection":["News &amp; Media Centre","Success Stories","Tobramycin","Vancomycin"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies","url":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies","name":"Bayesian Dosing of Tobramycin Outperforms Other Personalized Dosing Strategies at Pediatric Hospital &#8226; DoseMeRx","isPartOf":{"@id":"https:\/\/doseme-rx.com\/fr#website"},"primaryImageOfPage":{"@id":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies#primaryimage"},"image":{"@id":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies#primaryimage"},"thumbnailUrl":"https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/iStock-894463832_ped-pic.jpg","datePublished":"2023-03-15T14:36:31+00:00","dateModified":"2025-01-21T19:46:12+00:00","author":{"@id":"https:\/\/doseme-rx.com\/fr#\/schema\/person\/405846f0fce6edef593fe453fe3733dc"},"description":"Find out how Bayesian dosing of tobramycin with DoseMeRx reduces labs, saves time and money at The Children's Hospital at Westmead, Australia","breadcrumb":{"@id":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies#primaryimage","url":"https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/iStock-894463832_ped-pic.jpg","contentUrl":"https:\/\/doseme-rx.com\/wp-content\/uploads\/2023\/03\/iStock-894463832_ped-pic.jpg","width":2119,"height":1414},{"@type":"BreadcrumbList","@id":"https:\/\/doseme-rx.com\/fr\/tobramycin\/articles\/bayesian-dosing-of-tobramycin-outperforms-other-personalized-dosing-strategies#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/doseme-rx.com\/fr"},{"@type":"ListItem","position":2,"name":"Bayesian Dosing of Tobramycin Outperforms Other Personalized Dosing Strategies at Pediatric Hospital"}]},{"@type":"WebSite","@id":"https:\/\/doseme-rx.com\/fr#website","url":"https:\/\/doseme-rx.com\/fr","name":"DoseMeRx","description":"Choose us for our world-leading Bayesian dosing software. Stay with us for our best-in-class customer service.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/doseme-rx.com\/fr?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/doseme-rx.com\/fr#\/schema\/person\/405846f0fce6edef593fe453fe3733dc","name":"Brit Vezina","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/secure.gravatar.com\/avatar\/1090bf8f3a066ce91463d560b43aaed18218238355e985ed823e8d0146df3f6a?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/1090bf8f3a066ce91463d560b43aaed18218238355e985ed823e8d0146df3f6a?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/1090bf8f3a066ce91463d560b43aaed18218238355e985ed823e8d0146df3f6a?s=96&d=mm&r=g","caption":"Brit Vezina"},"url":"https:\/\/doseme-rx.com\/fr\/author\/bvezina"}]}},"_links":{"self":[{"href":"https:\/\/doseme-rx.com\/fr\/wp-json\/wp\/v2\/posts\/9937","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doseme-rx.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/doseme-rx.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/doseme-rx.com\/fr\/wp-json\/wp\/v2\/users\/32"}],"replies":[{"embeddable":true,"href":"https:\/\/doseme-rx.com\/fr\/wp-json\/wp\/v2\/comments?post=9937"}],"version-history":[{"count":17,"href":"https:\/\/doseme-rx.com\/fr\/wp-json\/wp\/v2\/posts\/9937\/revisions"}],"predecessor-version":[{"id":10592,"href":"https:\/\/doseme-rx.com\/fr\/wp-json\/wp\/v2\/posts\/9937\/revisions\/10592"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/doseme-rx.com\/fr\/wp-json\/wp\/v2\/media\/9951"}],"wp:attachment":[{"href":"https:\/\/doseme-rx.com\/fr\/wp-json\/wp\/v2\/media?parent=9937"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doseme-rx.com\/fr\/wp-json\/wp\/v2\/categories?post=9937"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doseme-rx.com\/fr\/wp-json\/wp\/v2\/tags?post=9937"},{"taxonomy":"article-type","embeddable":true,"href":"https:\/\/doseme-rx.com\/fr\/wp-json\/wp\/v2\/article-type?post=9937"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}