Healthcare Technology Report Feature: How DoseMe CEO is Helping Clinicians Dose Smarter Through Precision

When Paul Edwards, the President and Chief Executive Officer of DoseMe, first started working in the medical space, he was struck by the difficulties in using antibiotics to treat patients. “You had these very powerful antibiotics that you knew you couldn’t let everybody use,” he said in a 2024 interview, “but at the same time, a physician, because he knew so little about what was happening with the patient, would obviously always choose that big gun antibiotic.”

What Edwards realized was that doctors needed to dose smarter, which is the guiding principle behind DoseMe, which he’s run since 2023. In a world where drug development is happening faster and more aggressively than ever, Edwards is working to make sure those drugs are identified and administered to the patients for whom they’re intended, rather than leaving physicians to play guessing games.

He analogizes DoseMe’s process to someone attending a sporting event. Broadly speaking, you know where the stadium is, not unlike a doctor would, broadly speaking, be able to identify what could be wrong with a patient. But just as someone attending a football game would need to find their specific seat, DoseMe is designed to help a physician find precisely the right antibiotic with which to treat the patient.

DoseMe uses population-based modeling to do this, looking at several medical criteria – age, weight, ethnicity – in conjunction with a Bayesian statistical model, which “gives the clinician very precise information about what dose and for how long and how many times.” By so doing, DoseMe helps speed up every part of the often laborious process of receiving medical treatment, a timesaving effort with a long tail, especially when it comes to vancomycin, a drug used to treat specific bacterial infections.

“If you’re using trough-based dosing for vancomycin, you need to take blood levels probably every 12 to 24 hours,” Edwards said.”If you’re using Bayesian dosing, you take one blood level. You don’t take another one. So you’re saving on nursing time, you’re saving on pharmacy time, and you’re getting to your correct dose, your precise dose quicker than you would do with a trough-based dosing methodology, which is what we’ve used for 30, 40, 50 years.”

In enabling doctors to do their best work, Edwards is living his creed. He believes in surrounding himself with smart people and letting them shine – and, critically, he knows when to “get out of the way and let them do what they’re good at.”