Streamline oncology TDM with cutting-edge dosing software.

Simplify busulfan dosing for providers & patients with only two levels

Busulfan dosing is a complex process due to various factors that impact its effectiveness and safety. 

Busulfan drug exposure must be maintained within a narrow therapeutic range. If the drug exposure is too high, there is an increased risk of toxicity and of transplantation-related mortality. If the dose is too low, there is an increased probability of graft rejection or disease relapse. Additionally, accurately estimating the AUC and adjusting the dosage accordingly can be difficult.

Conventional methods of dosing busulfan also require multiple blood samples, typically around 5-8, to measure AUC. This frequent sampling is not only time-consuming for providers, but also increases patient discomfort.

There’s an easier way to dose! The challenges of busulfan dosing emphasize the need for advanced tools and technology, such as DoseMeRx, to simplify the dosing process and reduce the burden on patients. 

A study comparing the conventional multi-sample AUC estimation model of busulfan dosing in HCT patients with a two-sample protocol using DoseMeRx, found that DoseMeRx:

• Only needs two levels for an accurate estimate of AUC 
• Provides greater flexibility in the timing of levels 
• Achieves a therapeutic range quicker
  

The study also demonstrated that using only two levels can save time and optimize workflow for providers, as well as lessen patient distress.