The Benefits of Precision Dosing

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“[Aminoglycoside Bayesian dose individualization] is a well-accepted practice… [Further studies] may not be feasible for ethical reasons.” – Ho et al.

Precision dosing using Bayesian dose individualization has been shown to have such significant benefits that some leading researchers believe that further clinical trials may be unethical, due to the control arm being required to receive substandard treatment.

DoseMeRx uses Bayesian dosing to calculate a precise dose to achieve your clinical target. Studies have shown that this results in significant and substantial improvements to mortality, risk, and patient outcomes. To find out more, take a look at what other hospitals have achieved with Bayesian dosing.

Enhance Outcomes

The following papers are just some of the randomized clinical trials that show the patient benefits of precision dosing and dose-individualization:

  1. Increased survival for childhood leukaemia patients.
  2. Improved survival for septic patients.
  3. Increased patients in therapeutic range (chemotherapy).
  4. Increased proportion of patients in therapeutic range:
  5. Decreased time to therapeutic stabilisation.
  6. Shortened febrile periods:

Reduce Adverse Events

Precision dosing reduces adverse events. The following RCTs demonstrate some of these benefits:

  1. Reduced risk of toxic drug levels.
  2. Reduction in bleeding events.1
  3. Reduction in bruising events.1
  4. Halve side-effects for chemotherapy patients.
  5. Decreased discontinuation due to adverse events.
  6. Decreased nephrotoxicity:

Reduce Costs

Improving patient outcomes and reducing adverse events is highly cost-effective. The studies below quantify the cost-benefits of precision dosing:

  1. Cost-benefit ratio of between 4:1 and 52:1. (Review).
  2. Save $2,500 (USD, 2012) per patient.
  3. Substantial overall savings due to lowered mortality.
  4. Reduce hospital stay length by more than 6 days per patient.
  5. 4.6 day reduction in hospital stay length.
  6. Halve the number of assays required.

DoseMeRx Platform

Discover how simple DoseMeRx is to use, see what drug packages are available and find out more about our licenses here.

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