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Vancomycin dosing: to AUC or Not?
19 Oct 2018 | Latest News

Vancomycin dosing: to AUC or Not?

This month, the American Journal of Health System Pharmacists published ‘Making the change to area under the curve-based vancomycin dosing’ (Heil EL et al. AJHP. 2018) providing practical advice for implementing an AUC-based vancomycin dosing strategy for adult patients. The paper highlights population pharmacokinetic modelling with the use of...

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Making A Difference Through Optimizing Cyclosporine Treatment With DoseMe
24 Sep 2018 | Case Study

Making A Difference Through Optimizing Cyclosporine Treatment With DoseMe

THE CUSTOMER Maribor University Medical Centre is one of the largest medical institutions in Slovenia. It is a public health care institution performing healthcare services on secondary and tertiary level for the wider region of Maribor, Pesnica, Ruše, Ormož, Lenart, Ptuj and Slovenska Bistrica. THE CHALLENGE Despite the emergence of new drugs,...

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A New Approach to Therapeutic Drug Monitoring of Tobramycin in Cystic Fibrosis

A New Approach to Therapeutic Drug Monitoring of Tobramycin in Cystic Fibrosis

EXECUTIVE SUMMARY INTRODUCTION Intravenous (IV) tobramycin, an aminoglycoside antibiotic, is a standard treatment for Pseudomonas infection in patients with cystic fibrosis (CF). However, drug exposure must be maintained within a narrow therapeutic range. If the dose is too high, there is an increased risk of adverse events, such as nephrotoxicity and...

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Vancomycin Loading Dose: The Pharmacokinetics to Consider
4 Sep 2018 | Blog

Vancomycin Loading Dose: The Pharmacokinetics to Consider

A vancomycin loading dose – a large dose given once at the onset of therapy to rapidly achieve a therapeutic drug concentration – is required due to the pharmacokinetics of vancomycin to ensure that vancomycin levels are not subtherapeutic at the beginning of treatment. Vancomycin is a broad spectrum glycopeptide antibiotic...

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