EXECUTIVE SUMMARY INTRODUCTION Intravenous (IV) tobramycin, an aminoglycoside antibiotic, is a standard treatment for Pseudomonas infection in patients with cystic fibrosis (CF). However, drug exposure must be maintained within a narrow therapeutic range. If the dose is too high, there is an increased risk of adverse events, such as nephrotoxicity and...
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A vancomycin loading dose – a large dose given once at the onset of therapy to rapidly achieve a therapeutic drug concentration – is required due to the pharmacokinetics of vancomycin to ensure that vancomycin levels are not subtherapeutic at the beginning of treatment. Vancomycin is a broad spectrum glycopeptide antibiotic...
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DoseMe Chief Scientific Officer, Dr Robert McLeay, will present at this years International Association of Therapeutic Drug Monitoring and Clinical Toxicology Congress (IATDMCT) from 16-17 September in Brisbane, Australia. Dr McLeay will present his work on "Barriers overcome: A case study of deploying model-informed precision dosing across five...
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DoseMe today announced that DoseMeRx - the leading clinical decision support tool for precision dose calculations - has been selected for assessment by the University Hospitals of Leicester NHS Trust to optimize the dosing of vancomycin used in intensive care patients to treat MRSA blood stream infections. The project will evaluate...
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