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Clinical Evidence

Published studies and evidence support DoseMeRx achieving therapeutic doses of important medications to streamline operations, improve drug effectiveness and reduce adverse events.

Peer-reviewed Literature​

DoseMeRx has demonstrated clear clinical and operational benefits in independent peer-reviewed studies. 

DoseMeRx increases the proportion of vancomycin patients achieving target AUC24 and the percentage in target therapeutic range
Authors: Luqman Vali, David R Jenkins, Rakesh Vaja, Hussain Mulla | Download Paper

DoseMeRx (Bayesian estimation) accurately identifies patients at risk of AKI from just one assay
Authors: Chavada R, Ghosh N, Sandaradura I, Maley M, Van Hal SJ. | Download Paper

Comparing dosage adjustment methods for once-daily tobramycin in paediatric and adolescent patients with cystic fibrosis.
Authors: Hennig S, Holthouse F, Staatz CE. |Download Paper

Evaluation of Tobramycin Exposure Predictions in Three Bayesian Forecasting Programmes Compared with Current Clinical Practice in Children and Adults with Cystic Fibrosis.
Authors:  Burgard M, Sandaradura I, van Hal SJ, Stacey S, Hennig S.| Download Paper

Bayesian algorithms (such as those used in the models within DoseMeRx) enable sophisticated decision support that improves outcomes by customizing therapeutic drug doses for individual patients
Authors:  M Neely | Download Paper

Cyclosporine treatment for patients with autoimmune diseases shows improved therapeutic range and number of days in range by using DoseMeRx.
Authors:  Stopinšek, et. al | Download Paper

Case Studies

See how easily DoseMe can help you overcome challenges affecting your health system and how our customers are benefiting from DoseMeRx.

Optimizing Vancomycin AUC Dosing in Vascular Surgery Patients at University Hospitals of Leicester NHS Trust
DoseMeRx resulted in a significantly higher proportion of patients who reached the therapeutic AUC24 target improving outcomes in patients treated with vancomycin. | Read Online

Accurate Prediction of Vancomycin Levels to Optimize Care
DoseMeRx accurately predicts the concentration of vancomycin levels placing 84% of doses in target range. | Read Online

Making a Difference Through Optimizing Cyclosporine Treatment with DoseMe at Maribor University Medical Centre
The use of DoseMe to simplify the ability of UKC practitioners to optimise each patient’s cyclosporine therapy using only one concentration measurement. | Read Online

Therapeutic Drug Monitoring for Intravenous Busulfan: A Retrospective Analysis
DoseMeRx presents a clear opportunity to reduce the number of blood levels performed by 75% – improving operational efficiency without compromising patient outcomes. A trough assay and one assay at any other time will allow DoseMeRx to accurately calculate area under the curve (AUC). | Read Online

A New Approach to Therapeutic Drug Monitoring of Tobramycin in Cystic Fibrosis
The Dosing Institute reviews how DoseMeRx is shown to be more accurate at estimating AUC than the conventional two-sample method while requiring only one blood sample, and allowing the collection of this sample at a patient preferred time. | Read Online

Poster Presentations

DoseMeRx is continuously working on scientific poster presentations that are presented at conferences around the country.

AUC24 vancomycin Bayesian-based Dosing: Increasing Therapeutic Target Attainment with Decreased TDM cost
In this study, we compare therapeutic range attainment across five hospitals using vancomycin trough-based dosing versus five hospitals using Bayesian-supported vancomycin AUC24 based dosing. Poster presented at: ID Week Annual Meeting; October 4, 2019; Washington, DC. Download Poster

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